In addition, paw preference in canine species has also been associated with functional differences at both behavioral and physiological levels 23. vision 16, 17, auditory 18, olfaction 19) and paw preference has been widely reported in different motor tasks 20, 21, 22. The domestic dog may offer a valid animal model to study the relationship between motor lateralization and visuospatial attention mechanisms since the dog brain appears to be lateralized in a variety of perceptual sensory modalities (e.g. 2 reported an opposite lateralized pattern of shift in attention associated with drowsiness in a population of 26 right-handed and 26 non right-handed healthy humans, suggesting that the relationship of handedness with hemispheric lateralization for attention is task-dependent. Furthermore, during an auditory spatial localization task, Bareham et al. FMRI analysis reported a right-lateralized brain network associated with attention system in right-handed but not in left-handed subjects 15. Briefly, the leftward visuospatial bias was evident in both pecking activity and the order in which single pecks were made to the left and to the right-hand side of a surface uniformly spread with grains 11.Īlthough preferential handedness is one of the striking features of motor control in humans 12 and clear evidence exists that contralesional limb activation could reduce unilateral spatial neglect 13, 14, there are very few studies about how handedness may interact with spatial bias.Īn effect of handedness on spatial perceptual biases has been recently reported in human studies 2, 15. “pseudoneglect” phenomenon) 9, 10.Ī very similar leftward visuospatial bias was reported in a food detection task in which birds were required to explore an area in front of them and to sample grains 11. Neuropsychological tests in healthy human subjects, such as the cancellation task, provide further evidence of right hemisphere superiority in spatial attention, reporting a systematic leftward bias during “cancellation” of visual items on a sheet of paper placed midline in front of them (i.e. Taken together, these findings supported the hypothesis of a right hemispheric advantage in the control of spatial attention resources 8. However, left hemispatial neglect caused by damage to the right hemisphere occurs more than right hemispatial neglect due to left hemisphere stroke and asymmetries in recovery time show that right spatial neglect resolves more quickly than left (in other words, a right functionally-intact hemisphere can compensate for damaged left hemispheric spatial functions) 5, 6, 7. Attention deficit on the contralesional side of space following unilateral stroke (namely, unilateral spatial neglect) is a clear external manifestation of this phenomenon 3, 4. All rights reserved.It is well established that there is a complementary specialization of the two sides of the brain in terms of spatial attention, so that the right hemisphere processes information from the left visual field and the left hemisphere processes information from the right visual field 1, 2. These results are particularly significant as they point out that paying attention to potential individual hemispheric differences is important in both basic and clinical neuroscience.Īnimal model Clinical neuroscience Handedness Hemispheric asymmetries Laterality Rodents Translational neuroscience.Ĭopyright © 2021 Elsevier Ltd. However, contrary to what has been reported in humans, population level asymmetries were not observed. In mice, 81 % of animals showed a preference for either the left or the right paw, while 84 % of rats showed this preference. For both species, results indicate significant hemispheric asymmetries on the individual level. Here, we used meta-analysis to statistically integrate findings on paw preferences in rats and mice. Paw preference is one of the most frequently investigated forms of hemispheric asymmetries on the behavioural level. In particular, data on hemispheric asymmetries, an important organizational principle in the vertebrate brain, are conflicting as existing studies are often statistically underpowered due to small sample sizes. Despite their ubiquity as model species, many clinically relevant brain-behaviour relationships in rodents are not well understood. Mice and rats are among the most common animal model species in both basic and clinical neuroscience.
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